학술논문
Reduction of obliterative bronchiolitis (OB) by prolyl-hydroxylase-inhibitors activating hypoxia-inducible transcription factors in an experimental mouse model
Document Type
Article
Author
Source
In Transplant Immunology November 2016 39:66-73
Subject
Language
ISSN
0966-3274
Abstract
Highlights •ICA stabilizes HIF-α and induces HIF target genes within tracheal grafts•ICA procurement results in significantly reduced levels of luminal obliteration•Pre-treatment with ICA reduces intragraft cytokine- and adhesion molecule mRNA expression•ICA pretreatment decreases T cells and macrophages in ICA-pretreated grafts•Pharmaceutical inhibition of PHDs is an attractive strategy for organ preservation