학술논문


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'학술논문' 에서 검색결과 835건 | 목록 1~20
Academic Journal
IEEE Signal Processing Letters IEEE Signal Process. Lett. Signal Processing Letters, IEEE. 32:426-430 2025
How useful are the biochemical tests in guiding the diagnostic workup of infantile cholestasis? Background: The objective of our study was to determine whether biochemical tests, frequently requested at first presentation of infants with cholestasis, have a role in focusing investigations toward certain disease entities. Methods: All infants with cholestasis (2008 to 2020) were identified and reviewed for final diagnosis and serum levels of alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), lactate, cholesterol, ferritin, alpha-fetoprotein (AFP), total bile acids (TBAs), and hypoglycemia at first presentation. Results: ALT levels were normal in all infants with Dubin–Johnson syndrome. A normal TBA (0–10 μmol/L) in an infant with normal-GGT cholestasis was consistent with bile acids synthesis disorders (BASDs). There was a dichotomy pattern of "high-GGT cholestasis" [associated with biliary obstruction, Alagille syndrome, ciliopathies, mitochondrial hepatopathies] and "low GGT cholestasis", [associated with mutations in ATP8B1 , ABCB11 , TJP2 , USP53 , LSR , MYO5B , VIP AS39 , NR1H4 , BASD, galactosemia, gestational alloimmune liver disease (GALD), and endocrine causes]. Plasma lactate level was significantly elevated in infants with mitochondrial hepatopathies and hemophagocytic lymphohistiocytosis (HLH) [median 5.8 mmol/L and 7.7 mmo/L, respectively; P < 0.001]. The highest ferritin concentrations were in infants with HLH and GALD [medians 4883 μg/L and 2098 μg/L, respectively; P < 0.001]. The most marked elevation of AFP was consistent in all infants with mitochondrial hepatopathies, tyrosinemia, and GALD (median: 99637 ng/mL, 40000 ng/mL; 22566 ng/mL) as compared to causes of biliary obstruction (median: 3662 ng/mL). Hypoglycemia with preserved liver synthetic function was associated with metabolic or endocrine disorders. Conclusion: Although none of these biochemical tests is diagnostic in itself, they can be actionable
Academic Journal
Saudi Journal of Gastroenterology. Nov/Dec2025, Vol. 31 Issue 6, p373-382. 10p.
Book
La enseñanza-aprendizaje de ELE en Europa Oriental y los países bálticos ISBN: 9783111335360
Academic Journal
Front Reprod Health
Frontiers in Reproductive Health, Vol 5 (2023)
Academic Journal
Rieneck K; Laboratory of Blood Genetics, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark.; Rasmussen KK; Laboratory of Blood Genetics, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark.; Department of Technology, Faculty of Health and Technology, University College Copenhagen, Copenhagen, Denmark.; Schoof EM; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.; Clausen FB; Laboratory of Blood Genetics, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark.; Holze H; Novo Nordisk Foundation Center for Protein Research, Copenhagen, Denmark.; Bergholt T; Department of Obstetrics and Gynecology, Herlev Hospital, Herlev, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Jørgensen MH; Department of Pediatric and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark.; Christensen VB; Department of Pediatric and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark.; Almaas R; Department of Pediatric Research, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Jordal PL; SBT Instruments A/S, Herlev, Denmark.; Locard-Paulet M; Novo Nordisk Foundation Center for Protein Research, Copenhagen, Denmark.; Runager K; Teknologisk Institut, Aarhus C, Denmark.; Nielsen LK; Department of Technology, Faculty of Health and Technology, University College Copenhagen, Copenhagen, Denmark.; Schlotmann BC; Biotech Research & Innovation Centre, University of Copenhagen, Copenhagen, Denmark.; Weischenfeldt JL; Biotech Research & Innovation Centre, University of Copenhagen, Copenhagen, Denmark.; Jensen LJ; Novo Nordisk Foundation Center for Protein Research, Copenhagen, Denmark.; Dziegiel MH; Laboratory of Blood Genetics, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Book
Academic Journal
天津职业技术师范大学学报 / Journal of Tianjing University of Technology and Education. 28(1):71-74
Academic Journal
VESTNIK OF THE BASHKIR STATE AGRARIAN UNIVERSITY. 55:80-84
Academic Journal
Zeitschrift für Geburtshilfe und Neonatologie.
Academic Journal
IEEE Transactions on Very Large Scale Integration (VLSI) Systems IEEE Trans. VLSI Syst. Very Large Scale Integration (VLSI) Systems, IEEE Transactions on. 13(6):641-654 Jun, 2005
Conference
2008 International SoC Design Conference SoC Design Conference, 2008. ISOCC '08. International. 01:I-292-I-295 Nov, 2008
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