학술논문
'학술논문'
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1~10
Academic Journal
Simoes, MP; Hodcroft, EB; Simmonds, P; Albert, J; Alidjinou, EK; Ambert-Balay, K; Andrés, C; Antón, A; Auvray, C; Bailly, JL; Baldanti, F; Bastings, C; Beard, S; Pereira, CB; Berginc, N; Bloemen, M; Blomqvist, S; Bosma, F; Böttcher, S; Bubba, L; Buderus, S; Cabrerizo, M; Calvo, C; Celma, C; Ceriotti, F; Clark, G; Costa, I; Coste-Burel, M; Couderé, K; Cremer, J; Del Cuerpo Casas, M; Daehne, T; de Beer, J; de Ceano-Vivas, M; De Gascun, C; de Rougemont, A; Dean, J; Dembinski, JL; Diedrich, S; Diez-Domingo, J; Dillner, L; Dorenberg, DH; Ducancelle, A; Dudman, S; Dyrdak, R; Eis-Huebinger, AM; Falces-Romero, I; Farkas, A; Feeney, S; Fernandez-Garcia, MD; Flipse, J; Franck, KT; Galli, C; Garrigue, I; Geeraedts, F; Georgieva, I; Giardina, F; Guiomar, R; Hauzenberger, E; Heikens, E; Henquell, C; Hober, D; Hönemann, A; Howson-Wells, H; Hruškar, Ž; Ikonen, N; Imbert, B; Jansz, AR; Jeannoël, M; Jiřincová, H; Josset, L; Keeren, K; Kramer-Lindhout, N; Krokstad, S; Lazrek, M; Le Guillou-Guillemette, H; Lefeuvre, C; Lind, A; Lunar, MM; Maier, M; Marque-Juillet, S; McClure, CP; McKenna, J; Meijer, A; Menasalvas Ruiz, A; Mengual-Chuliá, B; Midgley, S; Mirand, A; Molenkamp, R; Montes, M; Moreno-Docón, A; Morley, U; Murk, JL; Navascués-Ortega, A; Nijhuis, R; Nikolaeva-Glomb, L; Nordbø, SA; Numanovic, S; Oggioni, M; Oñate Vergara, E; Pacaud, J; Pacreau, ML; Panning, M; Pariani, E; Pekova, L; Pellegrinelli, L; Petrovec, M; Pietsch, C; Pilorge, L; Piñeiro, L; Piralla, A; Poljak, M; Prochazka, B; Rabella, N; Rahamat-Langendoen, JC; Rainetova, P; Reynders, M; Riezebos-Brilman, A; Roorda, L; Savolainen-Kopra, C; Schuffenecker, I; Smeets, LC; Stoyanova, A; Stefic, K; Swanink, C; Tabain, I; Tjhie, J; Thouault, L; Tumiotto, C; Uceda Renteria, S; Uršič, T; Vallet, S; Van Ranst, M; Van Wunnik, P; Verweij, JJ; Vila, J; Wintermans, B; Wollants, E; Wolthers, KC; Xavier López-Labrado, F; Fischer, TK; Harvala, H; Benschop, KSM
The Journal of infectious diseases.
Academic Journal
Warren NA; Maskin SL; Gurupur V; Rector DA; Adelman D; Howell S; McAree J; Dibble R; Carlisano C; Maconi DP; Schrotenboer D; Jaimes M; Marte N; Carlisano T; Toland C; Chung J; Cremers SL; Corbin GS
Patient Related Outcome Measures, Vol Volume 15, Pp 143-186 (2024)
Academic Journal
Benschop, KSM; Broberg, EK; Hodcroft, E; Schmitz, D; Albert, J; Baicus, A; Bailly, JL; Baldvinsdottir, G; Berginc, N; Blomqvist, S; Bottcher, S; Brytting, M; Bujaki, E; Cabrerizo, M; Celma, C; Cinek, O; Claas, ECJ; Cremer, J; Dean, J; Dembinski, JL; Demchyshyna, I; Diedrich, S; Dudman, S; Dunning, J; Dyrdak, R; Emmanouil, M; Farkas, A; De Gascun, C; Fournier, G; Georgieva, I; Gonzalez-Sanz, R; Van Hooydonk-Elving, J; Jaaskelainen, AJ; Jancauskaite, R; Keeren, K; Fischer, TK; Krokstad, S; Nikolaeva-Glomb, L; Novakova, L; Midgley, SE; Mirand, A; Molenkamp, R; Morley, U; Mossong, J; Muralyte, S; Murk, JL; Nguyen, T; Nordbo, SA; Osterback, R; Pas, S; Pellegrinelli, L; Pogka, V; Prochazka, B; Rainetova, P; Van Ranst, M; Roorda, L; Schuffenecker, I; Schuurman, R; Stoyanova, A; Templeton, K; Verweij, JJ; Voulgari-Kokota, A; Vuorinen, T; Wollants, E; Wolthers, KC; Zakikhany, K; Neher, R; Harvala, H; Simmonds, P
Emerging infectious diseases. 27(6):1616-1626
Academic Journal
Barturen, G; Babaei, S; Catala-Moll, F; Martinez-Bueno, M; Makowska, Z; Martorell-Marugan, J; Carmona-Saez, P; Toro-Dominguez, D; Carnero-Montoro, E; Teruel, M; Kerick, M; Acosta-Herrera, M; Le Lann, L; Jamin, C; Rodriguez-Ubreva, J; Garcia-Gomez, A; Kageyama, J; Buttgereit, A; Hayat, S; Mueller, J; Lesche, R; Hernandez-Fuentes, M; Juarez, M; Rowley, T; White, I; Maranon, C; Anjos, TG; Varela, N; Aguilar-Quesada, R; Garrancho, FJ; Lopez-Berrio, A; Maresca, MR; Navarro-Linares, H; Almeida, I; Azevedo, N; Brandao, M; Campar, A; Faria, R; Farinha, F; Marinho, A; Neves, E; Tavares, A; Vasconcelos, C; Trombetta, E; Montanelli, G; Vigone, B; Alvarez-Errico, D; Li, TL; Thiagaran, D; Alonso, RB; Martinez, AC; Genre, F; Mejias, RL; Gonzalez-Gay, MA; Remuzgo, S; Garcia, BU; Cervera, R; Espinosa, G; Rodriguez-Pinto, I; De Langhe, E; Cremer, J; Lories, R; Belz, D; Hunzelmann, N; Baerlecken, N; Kniesch, K; Witte, T; Lehner, M; Stummvoll, G; Zauner, M; Aguirre-Zamorano, MA; Barbarroja, N; Castro-Villegas, MC; Collantes-Estevez, E; de Ramon, E; Quintero, ID; Escudero-Contreras, A; Roldan, MCF; Gomez, YJ; Moleon, IJ; Lopez-Pedrera, R; Ortega-Castro, R; Ortego, N; Raya, E; Artusi, C; Gerosa, M; Meroni, PL; Schioppo, T; De Groof, A; Ducreux, J; Lauwerys, B; Maudoux, AL; Cornec, D; Devauchelle-Pensec, V; Jousse-Joulin, S; Jouve, PE; Rouviere, B; Saraux, A; Simon, Q; Alvarez, M; Chizzolini, C; Dufour, A; Wynar, D; Balog, A; Bocskai, M; Deak, M; Dulic, S; Kadar, G; Kovacs, L; Cheng, QY; Gerl, V; Hiepe, F; Khodadadi, L; Thiel, S; de Rinaldis, E; Rao, S; Benschop, RJ; Chamberlain, C; Dow, ER; Ioannou, Y; Laigle, L; Marovac, J; Wojcik, J; Renaudineau, Y; Borghi, MO; Frostegard, J; Martin, J; Beretta, L; Ballestar, E; McDonald, F; Pers, JO; Alarcon-Riquelme, ME
Arthritis & rheumatology (Hoboken, N.J .). 73(6):1073-1085
Academic Journal
Albrecht M; Department of Anesthesiology and Intensive Care Medicine, University Hospital of Schleswig-Holstein, Kiel, Germany. martin.albrecht@uksh.de.; Hummitzsch L; Department of Anesthesiology and Intensive Care Medicine, University Hospital of Schleswig-Holstein, Kiel, Germany.; Rusch R; Clinic of Cardiovascular Surgery, University Hospital of Schleswig-Holstein, Kiel, Germany.; Eimer C; Department of Anesthesiology and Intensive Care Medicine, University Hospital of Schleswig-Holstein, Kiel, Germany.; Rusch M; Clinic of Cardiovascular Surgery, University Hospital of Schleswig-Holstein, Kiel, Germany.; Heß K; Department of Pathology, University Hospital of Schleswig-Holstein, Kiel, Germany.; Steinfath M; Department of Anesthesiology and Intensive Care Medicine, University Hospital of Schleswig-Holstein, Kiel, Germany.; Cremer J; Clinic of Cardiovascular Surgery, University Hospital of Schleswig-Holstein, Kiel, Germany.; Fändrich F; Clinic for Applied Cell Therapy, University Hospital of Schleswig-Holstein, Kiel, Germany.; Berndt R; Clinic of Cardiovascular Surgery, University Hospital of Schleswig-Holstein, Kiel, Germany.; Zitta K; Department of Anesthesiology and Intensive Care Medicine, University Hospital of Schleswig-Holstein, Kiel, Germany.
Publisher: Springer International Country of Publication: Germany NLM ID: 9504370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1440 (Electronic) Linking ISSN: 09462716 NLM ISO Abbreviation: J Mol Med (Berl) Subsets: MEDLINE
Academic Journal
Anna-Maria Makri Pistikou; Glenn A. O. Cremers; Bryan L. Nathalia; Theodorus J. Meuleman; Bas W. A. Bögels; Bruno V. Eijkens; Anne de Dreu; Maarten T. H. Bezembinder; Oscar M. J. A. Stassen; Carlijn C. V. Bouten; Maarten Merkx; Roman Jerala; Tom F. A. de Greef
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Academic Journal
Janine Reurink; Erik de Vrieze; Catherina H. Z. Li; Emma van Berkel; Sanne Broekman; Marco Aben; Theo Peters; Jaap Oostrik; Kornelia Neveling; Hanka Venselaar; Mariana Guimarães Ramos; Christian Gilissen; Galuh D. N. Astuti; Jordi Corominas Galbany; Janneke J. C. van Lith-Verhoeven; Charlotte W. Ockeloen; Lonneke Haer-Wigman; Carel B. Hoyng; Frans P. M. Cremers; Hannie Kremer; Susanne Roosing; Erwin van Wijk
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-9 (2022)
Academic Journal
Cells, Vol 11, Iss 24, p 3947 (2022)
Academic Journal
Blankenberg S; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Seiffert M; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Vonthein R; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Baumgartner H; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Bleiziffer S; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Borger MA; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Choi YH; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Clemmensen P; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Cremer J; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Czerny M; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Diercks N; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Eitel I; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Ensminger S; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Frank D; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Frey N; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Hagendorff A; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Hagl C; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Hamm C; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Kappert U; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Karck M; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Kim WK; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; König IR; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Krane M; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Landmesser U; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Linke A; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Maier LS; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Massberg S; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Neumann FJ; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Reichenspurner H; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Rudolph TK; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Schmid C; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Thiele H; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Twerenbold R; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Walther T; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Westermann D; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Xhepa E; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Ziegler A; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).; Falk V; From the Department of Cardiology and the Center for Population Health Innovation, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf (S. Blankenberg, M.S., P.C., N.D., R.T., A.Z.), German Center for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung [DZHK]) partner site Hamburg-Kiel-Lübeck (S. Blankenberg, M.S., P.C., J.C., N.D., I.E., S.E., D.F., I.R.K., H.R., R.T.), and the Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg (H.R.), Hamburg, the Department of Cardiology and Angiology, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum (M.S.), the Institute of Medical Biometry and Statistics, University of Lübeck (R.V., I.R.K.), the Departments of Cardiology, Angiology, and Intensive Care Medicine (I.E.) and Cardiovascular Surgery (S.E.), University Hospital of Schleswig-Holstein, Lübeck, the Department of Cardiology III-Adult Congenital and Valvular Heart Disease, University Hospital Münster, Müster (H.B.), the Departments of Thoracic and Cardiovascular Surgery (S. Bleiziffer) and General and Interventional Cardiology-Angiology (T.K.R.), Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, University Clinic of Cardiac Surgery (M.A.B.) and the Department of Internal Medicine (H.T.), Heart Center Leipzig at Leipzig University (M.A.B., H.T.), and Leipzig Heart Science (H.T.) and the Department of Cardiology at University Hospital Leipzig (A.H.), Leipzig, the Departments of Cardiac Surgery (Y.-H.C.) and Cardiology (W.-K.K.), Kerckhoff Clinic, Bad Nauheim, Medical Clinic I, the Department of Cardiology and Angiology, University of Giessen and Marburg (W.-K.K.), and Campus Kerckhoff and Medical Clinic I, University of Giessen (C. Hamm), Giessen, the Departments of Cardiovascular Surgery (J.C.) and Internal Medicine III (D.F.), University Hospital of Schleswig-Holstein, Kiel, Clinic for Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, University Clinic Freiburg, and the Faculty of Medicine, Albert Ludwigs University Freiburg (M.C.), and the Department of Cardiology and Angiology, University Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg (F.-J.N., D.W.), Freiburg, the Department of Cardiology, Angiology, and Pneumology, Heidelberg University Hospital (N.F.), DZHK partner site Heidelberg-Mannheim (N.F., M. Karck), and the Department of Cardiac Surgery, University Hospital Heidelberg (M. Karck), Heidelberg, the Departments of Cardiac Surgery (C. Hagl) and Cardiology (S.M.), University Hospital Munich, Ludwig Maximilians University Munich, DZHK partner site Munich Heart Alliance (C. Hagl, M. Krane, S.M., E.X.), and the Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, School of Medicine and Health (M. Krane), and the Department of Cardiology, German Heart Center Munich, Technical University of Munich (E.X.), Munich, DZHK partner site Rhine-Main, Rhine-Main (C. Hamm, W.-K.K., T.W.), the Departments of Cardiac Surgery (U.K.) and Internal Medicine and Cardiology (A.L.), Heart Center Dresden, University of Technology Dresden, Dresden, the Departments of Cardiology, Angiology, and Intensive Care Medicine (U.L.) and Cardiothoracic and Vascular Surgery (V.F.), Deutsches Herzzentrum der Charité, Charité University Medicine Berlin (U.L., V.F.), and DZHK partner site Berlin (U.L., V.F.), Berlin, the Departments of Internal Medicine II (L.S.M.) and Cardiothoracic Surgery (C.S.), University Medical Center Regensburg, Regensburg, and the Department of Cardiac and Vascular Surgery, University Hospital Frankfurt, Goethe University Frankfurt, Frankfurt am Main (T.W.) - all in Germany; the Division of Cardiac Surgery, Department of Surgery, Yale School of Medicine, New Haven, CT (M. Krane); Cardio-CARE, Medizincampus Davos, Davos (A.Z., S. Blankenberg), and the Department of Health Sciences and Technology, ETH Zurich, Translational Cardiovascular Technology, Zurich (V.F.) - both in Switzerland; and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).
Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE
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