부산대학교 도서관

Background: Cutaneous warts are common benign lesion of the skin and mucous membranes caused by an infection of the human papillomavirus (HPV). Approximately 100 different genotypes of HPV are known to date. High-risk HPV is generally found in immunocompromised patients; however, recently there have been some reports showing high-risk HPV in immunocompetent patients. Objectives: To identify the types of high risk HPV and that of HPV present in cutaneous warts in Korean patients. Methods: 104 common and plantar wart specimens were obtained through shave biopsy. The specimens were analyzed using the HPV28 detection assay, and 18 high-risk and 9 low-risk HPV were detected. Whole HPV genotyping was performed through a novel PCR method using the FAP59/FAP64 primer. Results: 104 specimens were analyzed and high-risk HPV 16 and 51 were detected in one specimen (each 1.0%). HPV was detected in 104 out of 67 specimens (64.4%). HPV 27 was found in 30 cases (44.8%), HPV 57 in 20 cases (29.9%), HPV 65 in 9 cases (13.4%), HPV 4 in 5 cases (7.5%), and HPV 7, 29, and 94 in 1 case each (1.5%). A statically significant association was observed between age and duration of warts at the time of diagnosis with the HPV genera (alpha vs gamma). Conclusion: The most common types of HPV in cutaneous warts in Korean patients were HPV 27, 57, 65, and 4. HPV 7, 29, and 94 were also observed. Except for HPV 16 and 51, the high-risk HPV was not seen in many cases.