부산대학교 도서관

Cancer poses a grave threat to human life and health, with drug therapy being a primary method widely employed in clinical oncology. However, the toxic side effects of these drugs continue to limit the effectiveness of chemotherapy. Surface modification of materials stands as one of the effective strategies to enhance drug-cell interactions and improve drug safety. Selenium, an essential trace element for the human body, is widely used in the design of nanomaterials due to its excellent antioxidant, antimutagenic, and anticancer properties. Through surface modification of selenium-based nanodrugs, a range of multifunctional composite selenium-containing nano-systems have been developed, enhancing drug stability, bioavailability, safety, and antitumor activity through multifunctional surface modifications. Herein, this article systematically reviews the latest advancements in the application of these selenium-containing nanostructures with multifunctional surface modifications in the biomedical field, providing novel perspectives for combination cancer therapies, and holds promise for pivotal roles in future cancer diagnostics and treatment.