학술논문
A platform of functional studies of ESCC-associated gene mutations identifies the roles of TGFBR2 in ESCC progression and metastasis
Document Type
Article
Author
Wang, Jian ; Du, Jiajia ; Luo, Xiangmeng ; Guo, Linjie ; Liu, Yixin ; Zhou, Jianfeng ; Zou, Yang ; Lu, Zhenghao ; Pan, Xiangyu ; Chen, Xuelan ; Zhong, Ailing ; Wan, Xudong ; Wang, Lu ; Liu, Hongyu ; Dai, Siqi ; Zhang, Shiyu ; Xiong, Xingyu ; Tan, Ping ; Wang, Manli ; Wu, Baohong ; Zhang, Qi ; Wang, Yingjie ; Zhang, Mengsha ; Lu, Runda ; Lin, Huahang ; Li, Yuan ; Li, Yaxin ; Han, Zongkai ; Chen, Longqi ; Hu, Bing ; Liu, Yu ; Na, Feifei ; Chen, Chong
Source
In Cell Reports 26 November 2024 43(11)
Subject
Language
ISSN
2211-1247
Abstract
@@@@Wang et al. generate a series of primary ESCC mouse models driven by different genetic mutations with premalignant esophageal organoids. Among them, TGFBR2-deficient ESCC, in which Smad3 activation is abnormally activated, can be targeted by pinaverium bromide, an FDA-approved calcium channel blocker.