학술논문
Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus
Document Type
Article
Author
Source
In Cell Reports 28 May 2024 43(5)
Subject
Language
ISSN
2211-1247
Abstract
Song et al. demonstrate that astrocyte-derived CHI3L1 engages with the CRTH2/RAGE receptor to impede neurogenesis and cognition by attenuating β-catenin signaling in the demyelinated hippocampus. CHI3L1 suppresses NSC proliferation via the CRTH2 receptor and hinders the neuronal development via the RAGE receptor rather than CRTH2.