학술논문
USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation
Document Type
Article
Author
Source
In Cell Reports 28 May 2024 43(5)
Subject
Language
ISSN
2211-1247
Abstract
@@@@Zhao et al. show that USP7 and TGF-β maintain high levels of Sα germline transcription and IgA switching by promoting RUNX3 expression at the posttranslational and transcriptional levels, respectively, thereby inhibiting upstream Sγ germline transcription and CSR.