학술논문
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation
Document Type
Article
Author
Gewartowska, Olga ; Aranaz-Novaliches, Goretti ; Krawczyk, Paweł S. ; Mroczek, Seweryn ; Kusio-Kobiałka, Monika ; Tarkowski, Bartosz ; Spoutil, Frantisek ; Benada, Oldrich ; Kofroňová, Olga ; Szwedziak, Piotr ; Cysewski, Dominik ; Gruchota, Jakub ; Szpila, Marcin ; Chlebowski, Aleksander ; Sedlacek, Radislav ; Prochazka, Jan ; Dziembowski, Andrzej
Source
In Cell Reports 20 April 2021 35(3)
Subject
Language
ISSN
2211-1247
Abstract
Secretion of collagens by osteoblasts is required for bone formation. Gewartowska et al. describe a mechanism in which a TENT5A-mediated wave of cytoplasmic polyadenylation regulates collagen expression. TENT5A dysfunction leads to a congenital bone disease known as osteogenesis imperfecta, the symptoms of which are recapitulated by Tent5a KO mice.