학술논문
Purification and characterization of a glycoprotein from Sipunculus nudus and its immune-enhancing activity to RAW 264.7 macrophages
Document Type
Article
Author
Lu, Xuli ; Dai, Yaping ; Yang, Shengtao ; Fu, Tengfei ; He, Yunxia ; Zeng, Fanke ; Chen, Tinghui ; Cao, Yupo ; Li, Ruyi ; Li, Jihua ; Zhou, Wei
Source
In Food Research International December 2023 174 Part 1
Subject
Language
ISSN
0963-9969
Abstract
Highlights •A glycoprotein (SGP1) was isolated from Sipunculus nudus for the first time.•SGP1 is a protein-dominate glycoprotein with O-glycosidic bonds containing 92.8% protein.•SGP1 was a predominantly β-sheet glycoprotein.•SGP1 exhibited strong immune-enhancing activity by promoting proliferation, phagocytosis and the secretions of NO, IL-1β, TNF-α and IL-6 on RAW264.7 cells.•SGP1 exerts immune-enhancing activity via NF-κB signaling pathway.