학술논문
SIRT7 protects against liver fibrosis by suppressing stellate cell activation via TGF-β/SMAD2/3 pathway
Document Type
Article
Author
Source
In Biomedicine & Pharmacotherapy November 2024 180
Subject
Language
ISSN
0753-3322
Abstract
Highlights •Knockout of SIRT7 in myeloid cells resulted in more severe liver fibrosis after CCl4.•SIRT7 is critical in regulating hepatic stellate cells activation via SMAD2/3.•SMAD2/3 is responsible for SIRT7 mediated HSCs activation and liver fibrosis regulation.