학술논문
Ropivacaine and celecoxib-loaded injectable composite hydrogel for improved chronic pain-exacerbated myocardial ischemia-reperfusion injury
Document Type
Article
Author
Wu, Fancan ; He, Wanyou ; Song, Da ; Wu, Zhen ; Dai, Peng ; Zheng, Xueqin ; Wang, Hanbing ; Xie, Chao
Source
In Journal of Controlled Release 10 March 2025 379:266-284
Subject
Language
ISSN
0168-3659
Abstract
@@@@Highlights •Chronic pain leads to hyperactivity of the SCG-cardiac sympathetic circuit, thereby exacerbating MI/R injury.•Chronic pain induces sympathetic hyperactivity via upregulation of TNF-α in sympathetic neurons.•CLDAFR hydrogel, targeting the SCG, provides prolonged celecoxib and ropivacaine release to alleviate chronic pain-exacerbated MI/R injury.