학술논문
Investigating residual trace metals in recombinant monoclonal antibodies to facilitate drug development with LC-UV-ICPMS-HRMS
Document Type
Article
Author
Source
In Analytica Chimica Acta 8 February 2025 1338
Subject
Language
ISSN
0003-2670
Abstract
@@@@Highlights •Online LC-UV-ICPMS-HRMS method to investigate metal speciation and metal-mAb interactions.•Capability to simultaneously detect metals and identify metal binding molecules.•Capability to pinpoint the location of metal binding on mAbs with integration of enzyme assisted subunit analysis.•Effective method to directly facilitate exploration of metal-mAb interactions during drug development.