학술논문
Clinical Characteristics and Outcomes of 905 COVID-19 Patients Admitted to Imam Khomeini Hospital Complex in the Capital City of Tehran, Iran.
Document Type
Article
Author
Allameh, Seyed Farshad; Nemati, Saeed; Ghalehtaki, Reza; Mohammadnejad, Esmaeil; Aghili, Seyed Mojtaba; Khajavirad, Nasim; Beigmohammadi, Mohammad-Taghi; Salehi, Mohammadreza; Mirfazaelian, Hadi; Edalatifard, Maryam; Kazemizadeh, Hossein; Dehghan Manshadi, Seyed Ali; Hasannezhad, Maliheh; Amoozadeh, Laya; Radnia, Masoud; Khatami, Seyedeh Rana; Nahvijou, Azin; Seyyedsalehi, Monireh Sadat; Rashidian, Laleh; Yazdi, Niloofar Ayoobi
Source
Subject
*AGE distribution
*ARTIFICIAL respiration
*C-reactive protein
*COMPUTED tomography
*CONFIDENCE intervals
*DEATH
*LENGTH of stay in hospitals
*HOSPITALS
*HOSPITAL admission & discharge
*INTENSIVE care units
*LACTATE dehydrogenase
*PATIENTS
*REGRESSION analysis
*RNA
*COMORBIDITY
*SYMPTOMS
*TREATMENT effectiveness
*DISEASE incidence
*SEVERITY of illness index
*DESCRIPTIVE statistics
*COVID-19
*HYDROXYCHLOROQUINE
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Language
ISSN
1029-2977
Abstract
Background: We studied the clinical characteristics and outcomes of 905 hospitalized coronavirus disease 2019 (COVID-19) patients admitted to Imam Khomeini Hospital Complex (IKHC), Tehran, Iran. Methods: COVID-19 patients were recruited based on clinical symptoms and patterns of computed tomography (CT) imaging between February 20 and March 19. All patients were tested for the presence of COVID-19 RNA. The Poisson regression model estimated the incidence rate ratio (IRR) for different parameters. Results: The average age (± standard deviation) was 56.9 (±15.7) years and 61.77% were male. The most common symptoms were fever (93.59%), dry cough (79.78%), and dyspnea (75.69%). Only 43.76% of patients were positive for the RT-PCR COVID-19 test. Prevalence of lymphopenia was 42.9% and more than 90% had elevated lactate dehydrogenase (LDH) or C-reactive protein (CRP). About 11% were severe cases, and 13.7% died in the hospital. The median length of stay (LOS) was 3 days. We found higher risks of mortality in patients who were older than 70 years (IRR = 11.77, 95% CI 3.63--38.18), underwent mechanical ventilation (IRR = 7.36, 95% CI 5.06--10.7), were admitted to the intensive care unit (ICU) (IRR = 5.47, 95% CI 4.00--8.38), tested positive on the COVID-19 test (IRR = 2.80, 95% CI 1.64--3.55), and reported a history of comorbidity (IRR = 1.76, 95% CI 1.07--2.89) compared to their corresponding reference groups. Hydroxychloroquine therapy was not associated with mortality in our study. Conclusion: Older age, experiencing a severe form of the disease, and having a comorbidity were the most important prognostic factors for COVID-19 infection. Larger studies are needed to perform further subgroup analyses and verify high-risk groups. [ABSTRACT FROM AUTHOR]