학술논문

In vitro activities of antifungal drugs against a large collection of Trichophyton tonsurans isolated from wrestlers.
Document Type
Article
Source
Mycoses. Dec2020, Vol. 63 Issue 12, p1321-1330. 10p.
Subject
*ITRACONAZOLE
*TRICHOPHYTON
*WRESTLERS
*CLOTRIMAZOLE
*DRUGS
*FLUCONAZOLE
Language
ISSN
0933-7407
Abstract
Summary: Background: Trichophyton tonsurans is the most common agent causing tinea gladiatorum in wrestlers, and limited data on susceptibility profiles of Trichophyton tonsurans are available. Objectives: We aimed to assess the in vitro activity of the common antifungal drug against a large collection of T tonsurans. Materials/Methods: The in vitro activities to eight common antifungal drugs (sertaconazole, itraconazole, clotrimazole, fluconazole, butenafine, tolnaftate, terbinafine and griseofulvin) against 128 clinical isolates of T tonsurans strains, obtained from wrestlers with dermatophytosis, were performed according to CLSI M38‐A2 broth microdilution document. Results: The geometric mean minimum inhibitory concentration was the lowest for tolnaftate (0.022 µg/mL), followed by itraconazole (0.026 µg/mL), terbinafine (0.033 µg/mL), butenafine (0.088 µg/mL), griseofulvin (0.566 µg/mL), sertaconazole (2.875 µg/mL), clotrimazole (3.419 µg/mL) and fluconazole (12.540 µg/mL). Conclusions: Evaluation of antifungal susceptibility of dermatophytes showed that tolnaftate and itraconazole were the most effective drugs against T tonsurans and fluconazole had the least effect. [ABSTRACT FROM AUTHOR]