학술논문
Burden of Skin and Subcutaneous Diseases in Iran and Neighboring Countries: Results from the Global Burden of Disease Study 2015.
Document Type
Article
Author
Karimkhani, Chante; Dellavalle, Robert P.; Karimi, Seyed M.; Rahimi-Movaghar, Vafa; Pourmalek, Farshad; Kiadaliri, Aliasghar A.; Sahraian, Mohammad Ali; Roshandel, Gholamreza; Fereshtehnejad, Seyed-Mohammad; Qorbani, Mostafa; Radfar, Amir; Farvid, Maryam S.; Asayesh, Hamid; Sepanlou, Sadaf G.; Djalalinia, Shirin; Kasaeian, Amir; Khubchandani, Jagdish; Malekzadeh, Reza; Moradi-Lakeh, Maziar; Krohn, Kristopher J.
Source
Subject
*GLOBAL burden of disease
*ACNE
*BASAL cell carcinoma
*STATISTICAL correlation
*DISEASES
*LIFE expectancy
*HEALTH policy
*PEOPLE with disabilities
*PROBABILITY theory
*REGRESSION analysis
*SEX distribution
*SKIN diseases
*SKIN inflammation
*SQUAMOUS cell carcinoma
*STATISTICAL hypothesis testing
*SURVEYS
*WORLD health
*LITERATURE reviews
*SOCIOECONOMIC factors
*DISEASE prevalence
*DATA analysis software
*DESCRIPTIVE statistics
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Language
ISSN
1029-2977
Abstract
Background: Iran and its neighboring countries represent four world regions with unique cultures and geography. Skin diseases span a wide diversity of etiologies including infectious, inflammatory, autoimmune, vascular, neurogenic, and oncologic. The Global Burden of Disease Study (GBD) 2015 measures the burden from skin diseases in 195 countries. Methods: Epidemiologic data were collected from literature review, survey data, and hospital inpatient/outpatient claims data. These raw data entered modeling using a Bayesian meta-regression tool, DisMod MR-2.1, which yielded prevalence estimates by age/sex/location/ year. Prevalence estimateswere combined with disability weights to yield years lived with disability (YLDs). YLDs are combined with years of life lost (YLLs), from mortality estimates, to yield disability-adjusted life years (DALYs). DALYs were obtained for 16 skin conditions and both sexes in Iran and 15 surrounding countries. The sociodemographic index (SDI) for each country was also correlated with skin disease DALY rate using the Pearson coefficient (r) with two-tailed p-value. Results: There was no significant correlation between individual skin diseases and SDI. Acne and dermatitis caused the greatest burden and BCC the lowestburden ofskin diseases in Iran and the other15countries. SCC and BCCwere responsible forthe largestdiscrepancy by sex, with higher burden in males compared to females. Conclusion: Skin diseases, particularly dermatitis and acne, cause considerable burden in Iran and surrounding regions. Objective and transparentepidemiologic data such asGBD hasthe potential to inform and impactmanyfacetsofhealthcare, research prioritization, public policy, and international partnerships. [ABSTRACT FROM AUTHOR]