학술논문
IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update
Document Type
Author
Pedersen, Nancy L.; Gatz, Margaret; Finch, Brian K; Finkel, Deborah; Butler, David A.; Dahl Aslan, Anna K., 1975; Franz, Carol E.; Kaprio, Jaakko; Lapham, Susan; McGue, Matt; Mosing, Miriam A.; Neiderhiser, Jenae; Nygaard, Marianne; Panizzon, Matthew; Prescott, Carol A.; Reynolds, Chandra A.; Sachdev, Perminder; Whitfield, Keith E.
Source
Twin Research and Human Genetics. 22(6):809-816
Subject
Language
English
ISSN
1832-4274
1839-2628
1839-2628
Abstract
The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene-environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14-103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.