학술논문
Setting a baseline for global urban virome surveillance in sewage
Document Type
Author
Nieuwenhuijse, David F.; Oude Munnink, Bas B.; Phan, My V.T.; Hendriksen, Rene S.; Bego, Artan; Rees, Catherine; Neilson, Elizabeth Heather; Coventry, Kris; Collignon, Peter; Allerberger, Franz; Rahube, Teddie O.; Oliveira, Guilherme; Ivanov, Ivan; Sopheak, Thet; Vuthy, Yith; Yost, Christopher K.; Tabo, Djim adjim; Cuadros-Orellana, Sara; Ke, Changwen; Zheng, Huanying; Baisheng, Li; Jiao, Xiaoyang; Donado-Godoy, Pilar; Coulibaly, Kalpy Julien; Hrenovic, Jasna; Jergović, Matijana; Karpíšková, Renáta; Elsborg, Bodil; Legesse, Mengistu; Eguale, Tadesse; Heikinheimo, Annamari; Villacis, Jose Eduardo; Sanneh, Bakary; Malania, Lile; Nitsche, Andreas; Brinkmann, Annika; Saba, Courage Kosi Setsoafia; Kocsis, Bela; Solymosi, Norbert; Thorsteinsdottir, Thorunn R.; Hatha, Abdulla Mohamed; Alebouyeh, Masoud; Morris, Dearbhaile; O’Connor, Louise; Cormican, Martin; Moran-Gilad, Jacob; Battisti, Antonio; Alba, Patricia; Shakenova, Zeinegul; Kiiyukia, Ciira; Ng’eno, Eric; Raka, Lul; Bērziņš, Aivars; Avsejenko, Jeļena; Bartkevics, Vadims; Penny, Christian; Rajandas, Heraa; Parimannan, Sivachandran; Haber, Malcolm Vella; Pal, Pushkar; Schmitt, Heike; van Passel, Mark; van de Schans, Milou G.M.; Zuidema, Tina; Jeunen, Gert Jan; Gemmell, Neil; Fashae, Kayode; Wester, Astrid Louise; Holmstad, Rune; Hasan, Rumina; Shakoor, Sadia; Rojas, Maria Luz Zamudio; Wasyl, Dariusz; Bosevska, Golubinka; Kochubovski, Mihail; Radu, Cojocaru; Gassama†, Amy; Radosavljevic, Vladimir; Tay, Moon Y.F.; Zuniga-Montanez, Rogelio; Wuertz, Stefan; Gavačová, Dagmar; Trkov, Marija; Keddy, Karen; Esterhuyse, Kerneels; Cerdà-Cuéllar, Marta; Pathirage, Sujatha; Larsson, D. G. Joakim, 1969; Norrgren, Leif; Örn, Stefan; Van der Heijden, Tanja; Kumburu, Happiness Houka; de RodaHusman, Ana Maria; Njanpop-Lafourcade, Berthe Marie; Bidjada, Pawou; Nikiema-Pessinaba, Somtinda Christelle; Levent, Belkis; Meschke, John Scott; Beck, Nicola Koren; Van Dang, Chinh
Source
Scientific Reports. 10
Subject
Language
English
ISSN
2045-2322
Abstract
© 2020, The Author(s). The rapid development of megacities, and their growing connectedness across the world is becoming a distinct driver for emerging disease outbreaks. Early detection of unusual disease emergence and spread should therefore include such cities as part of risk-based surveillance. A catch-all metagenomic sequencing approach of urban sewage could potentially provide an unbiased insight into the dynamics of viral pathogens circulating in a community irrespective of access to care, a potential which already has been proven for the surveillance of poliovirus. Here, we present a detailed characterization of sewage viromes from a snapshot of 81 high density urban areas across the globe, including in-depth assessment of potential biases, as a proof of concept for catch-all viral pathogen surveillance. We show the ability to detect a wide range of viruses and geographical and seasonal differences for specific viral groups. Our findings offer a cross-sectional baseline for further research in viral surveillance from urban sewage samples and place previous studies in a global perspective.