학술논문
Cerebrospinal fluid neurofilament light predicts longitudinal diagnostic change in patients with psychiatric and neurodegenerative disorders
Document Type
Author
Kang, Matthew J.Y.; Eratne, Dhamidhu; Dobson, Hannah; Malpas, Charles B.; Keem, Michael; Lewis, Courtney; Grewal, Jasleen; Tsoukra, Vivian; Dang, Christa; Mocellin, Ramon; Kalincik, Tomas; Santillo, Alexander F.; Zetterberg, Henrik; Blennow, Kaj; Stehmann, Christiane; Varghese, Shiji; Li, Qiao Xin; Masters, Colin L.; Collins, Steven; Berkovic, Samuel F.; Evans, Andrew; Kelso, Wendy; Farrand, Sarah; Loi, Samantha M.; Walterfang, Mark; Velakoulis, Dennis
Source
Acta Neuropsychiatrica MultiPark: Multidisciplinary research focused on Parkinson´s disease. 36(1):17-28
Subject
Language
English
ISSN
0924-2708
Abstract
Objective People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY), its accuracy in a diagnostically challenging cohort longitudinally is unknown. Methods We collected longitudinal diagnostic information (mean=36 months) from patients assessed at a neuropsychiatry service, categorising diagnoses as ND/mild cognitive impairment/other neurological disorders (ND/MCI/other), and PSY. We pre-specified NfL>582pg/mL as indicative of ND/MCI/other. Results Diagnostic category changed from initial to final diagnosis for 23% (49/212) of patients. NfL predicted the final diagnostic category for 92% (22/24) of these and predicted final diagnostic category overall (ND/MCI/other vs. PSY) in 88% (187/212), compared to 77% (163/212) with clinical assessment alone. Conclusions CSF NfL improved diagnostic accuracy, with potential to have led to earlier, accurate diagnosis in a real-world setting using a pre-specified cut-off, adding weight to translation of NfL into clinical practice.