학술논문
Method of encapsulating polyaminopolycarboxylic acid chelating agents in liposomes
Document Type
Patent
Author
Source
Patent File Date: Filed date 10 Nov 1975; Other Information: PAT-APPL-630,474
Subject
Language
English
Abstract
A method is provided for transferring a polyaminopolycarboxylic acid chelating agent across a cellullar membrane by encapsulating the charged chelating agent within liposomes, which liposomes will be taken up by the cells, thereby transferring the chelating agent across the cellular membrane. The chelating agent is encapsulated within liposomes by drying a lipid mixture to form a thin film and wetting the lipid film with a solution containing the chelating agent. Mixing then results in the formation of a suspension of liposomes encapsulating the chelating agent, which liposomes can then be separated.