학술논문
Pharmacological properties of specioside from the stem bark of Tabebuia aurea
Document Type
Original Paper
Author
Nocchi, Samara Requena; Kato, Natália Naomi; de Almeida, Julio Menta; Ferreira, Alda Maria Teixeira; Toffoli-Kadri, Mônica Cristina; de Freitas Meirelles, Lyvia Eloiza; Damke, Gabrielle Marconi Zago Ferreira; Consolaro, Marcia Edilaine Lopes; Rigo, Graziela Vargas; Macedo, Alexandre José; Tasca, Tiana; dos Reis, Sharon Vieira; Alves, Flavio Macedo; Carollo, Carlos Alexandre; Silva, Denise Brentan
Source
Revista Brasileira de Farmacognosia: Brazilian Journal of Pharmacognosy. 30(1):118-122
Subject
Language
English
ISSN
1981-528X
Abstract
Iridoids are secondary metabolites with several biological activities. They are often found in species of the genus Tabebuia Gomes ex A.P. de Candolle. Tabebuia aurea (Silva Manso) Benth. & Hook. F. ex S. Moore, Bignoniaceae, is used to treat snake bites in traditional medicine. This study aimed to isolate the specioside - an the iridoid glycoside - from T. aurea, as well as investigate its potential biological properties, including anti-inflammatory, antibacterial, antibiofilm, cytotoxic, anti-Trichomonas vaginalis and antitrypanosomal activities. Specioside inhibited leucocyte recruitment into the peritoneal cavity in mice injected with carrageenan, data that demonstrated its anti-inflammatory potential. However, the additional evaluated biological properties were negligible.