학술논문
Rietveld Method in the Analysis of Polymorphism in Mebendazole Tablets Acquired in Brazil’s Drugstores
Document Type
article
Source
Journal of the Brazilian Chemical Society. September 2015 26(9)
Subject
Language
English
ISSN
0103-5053
Abstract
Mebendazole (MBZ) is an anthelmintic medicine known to exhibit the polymorphs A, B and C, where polymorph C is the one indicated for tablets. Mebendazole commercial tablets (references, generics and similars) were analyzed in this work using X-ray powder diffraction data and the Rietveld method (RM) aiming at characterizing and quantifying crystal phases. Form C was found in mixture with form A in formulations of 500 mg (reference and generic). One of the generics presented a batch with form B and another one with form C. All the other tablets presented form A.