학술논문
Early biochemical outcomes following PSMA guided approach for bIoCHEmical relapse after prostatectomy-PSICHE trial (NCT05022914): preliminary results
Document Type
article
Author
Francolini, Giulio; Ganovelli, Michele; Di Cataldo, Vanessa; Detti, Beatrice; Caini, Saverio; Loi, Mauro; Simontacchi, Gabriele; Desideri, Isacco; Greto, Daniela; Valzano, Marianna; Serni, Sergio; Vaggelli, Luca; Salvestrini, Viola; Visani, Luca; Becherini, Carlotta; Olmetto, Emanuela; Franzese, Ciro; Baldaccini, Davide; Scorsetti, Marta; Sollini, Martina; Chiti, Arturo; Meattini, Icro; Valicenti, Richard K; Livi, Lorenzo
Source
Clinical & Experimental Metastasis. 40(2)
Subject
Language
Abstract
PSICHE (NCT05022914) is a prospective trial to test a [68Ga]Ga- PSMA-11 PET/CT imaging tailored strategy. All evaluable patients had biochemical relapse after surgery and underwent centralized [68Ga]Ga-PSMA-11 PET/CT imaging. The treatment was performed according pre-defined criteria. Observation and re-staging at further PSA progression were proposed to patients with negative PSMA and previous postoperative RT. Prostate bed SRT was proposed to all patients with a negative staging or positive imaging within prostate bed. Stereotactic body radiotherapy (SBRT) to all sites of disease was used for all patients with pelvic nodal recurrence (nodal disease