학술논문
Breast biopsy patterns and findings among older women undergoing screening mammography: The role of age and comorbidity
Document Type
article
Author
Advani, Shailesh; Abraham, Linn; Buist, Diana SM; Kerlikowske, Karla; Miglioretti, Diana L; Sprague, Brian L; Henderson, Louise M; Onega, Tracy; Schousboe, John T; Demb, Joshua; Zhang, Dongyu; Walter, Louise C; Lee, Christoph I; Braithwaite, Dejana; O'Meara, Ellen S; Consortium, for the Breast Cancer Surveillance
Source
Journal of Geriatric Oncology. 13(2)
Subject
Language
Abstract
IntroductionLimited evidence exists on the impact of age and comorbidity on biopsy rates and findings among older women.Materials and methodsWe used data from 170,657 women ages 66-94 enrolled in the United States Breast Cancer Surveillance Consortium (BCSC). We estimated one-year rates of biopsy by type (any, fine-needle aspiration (FNA), core or surgical) and yield of the most invasive biopsy finding (benign, ductal carcinoma in situ (DCIS) and invasive breast cancer) by age and comorbidity. Statistical significance was assessed using Wald statistics comparing coefficients estimated from logistic regression models adjusted for age, comorbidity, BCSC registry, and interaction between age and comorbidity.ResultsOf 524,860 screening mammograms, 9830 biopsies were performed following 7930 exams (1.5%) within one year, specifically 5589 core biopsies (1.1%), 3422 (0.7%) surgical biopsies and 819 FNAs (0.2%). Biopsy rates per 1000 screens decreased with age (66-74:15.7, 95%CI:14.8-16.8), 75-84:14.5(13.5-15.6), 85-94:13.2(11.3,15.4), ptrend