학술논문
Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function
Document Type
article
Author
Xu, Jiayi; Bartz, Traci M; Chittoor, Geetha; Eiriksdottir, Gudny; Manichaikul, Ani W; Sun, Fangui; Terzikhan, Natalie; Zhou, Xia; Booth, Sarah L; Brusselle, Guy G; de Boer, Ian H; Fornage, Myriam; Frazier-Wood, Alexis C; Graff, Mariaelisa; Gudnason, Vilmundur; Harris, Tamara B; Hofman, Albert; Hou, Ruixue; Houston, Denise K; Jacobs, David R; Kritchevsky, Stephen B; Latourelle, Jeanne; Lemaitre, Rozenn N; Lutsey, Pamela L; O’Connor, George; Oelsner, Elizabeth C; Pankow, James S; Psaty, Bruce M; Rohde, Rebecca R; Rich, Stephen S; Rotter, Jerome I; Smith, Lewis J; Stricker, Bruno H; Voruganti, V Saroja; Wang, Thomas J; Zillikens, M Carola; Barr, R Graham; Dupuis, Josée; Gharib, Sina A; Lahousse, Lies; London, Stephanie J; North, Kari E; Smith, Albert V; Steffen, Lyn M; Hancock, Dana B; Cassano, Patricia A
Source
British Journal Of Nutrition. 120(10)
Subject
Language
Abstract
The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)-pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P