학술논문
microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data
Document Type
article
Author
Zuffa, Simone; Schmid, Robin; Bauermeister, Anelize; P. Gomes, Paulo Wender; Caraballo-Rodriguez, Andres M; El Abiead, Yasin; Aron, Allegra T; Gentry, Emily C; Zemlin, Jasmine; Meehan, Michael J; Avalon, Nicole E; Cichewicz, Robert H; Buzun, Ekaterina; Terrazas, Marvic Carrillo; Hsu, Chia-Yun; Oles, Renee; Ayala, Adriana Vasquez; Zhao, Jiaqi; Chu, Hiutung; Kuijpers, Mirte CM; Jackrel, Sara L; Tugizimana, Fidele; Nephali, Lerato Pertunia; Dubery, Ian A; Madala, Ntakadzeni Edwin; Moreira, Eduarda Antunes; Costa-Lotufo, Leticia Veras; Lopes, Norberto Peporine; Rezende-Teixeira, Paula; Jimenez, Paula C; Rimal, Bipin; Patterson, Andrew D; Traxler, Matthew F; Pessotti, Rita de Cassia; Alvarado-Villalobos, Daniel; Tamayo-Castillo, Giselle; Chaverri, Priscila; Escudero-Leyva, Efrain; Quiros-Guerrero, Luis-Manuel; Bory, Alexandre Jean; Joubert, Juliette; Rutz, Adriano; Wolfender, Jean-Luc; Allard, Pierre-Marie; Sichert, Andreas; Pontrelli, Sammy; Pullman, Benjamin S; Bandeira, Nuno; Gerwick, William H; Gindro, Katia; Massana-Codina, Josep; Wagner, Berenike C; Forchhammer, Karl; Petras, Daniel; Aiosa, Nicole; Garg, Neha; Liebeke, Manuel; Bourceau, Patric; Kang, Kyo Bin; Gadhavi, Henna; de Carvalho, Luiz Pedro Sorio; Silva dos Santos, Mariana; Pérez-Lorente, Alicia Isabel; Molina-Santiago, Carlos; Romero, Diego; Franke, Raimo; Brönstrup, Mark; Vera Ponce de León, Arturo; Pope, Phillip Byron; La Rosa, Sabina Leanti; La Barbera, Giorgia; Roager, Henrik M; Laursen, Martin Frederik; Hammerle, Fabian; Siewert, Bianka; Peintner, Ursula; Licona-Cassani, Cuauhtemoc; Rodriguez-Orduña, Lorena; Rampler, Evelyn; Hildebrand, Felina; Koellensperger, Gunda; Schoeny, Harald; Hohenwallner, Katharina; Panzenboeck, Lisa; Gregor, Rachel; O’Neill, Ellis Charles; Roxborough, Eve Tallulah; Odoi, Jane; Bale, Nicole J; Ding, Su; Sinninghe Damsté, Jaap S; Guan, Xue Li; Cui, Jerry J; Ju, Kou-San; Silva, Denise Brentan; Silva, Fernanda Motta Ribeiro; da Silva, Gilvan Ferreira; Koolen, Hector HF; Grundmann, Carlismari; Clement, Jason A
Source
Nature Microbiology. 9(2)
Subject
Language
Abstract
microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identification of microbe-derived metabolites and relative producers without a priori knowledge will vastly enhance the understanding of microorganisms' role in ecology and human health.