학술논문
Obesity in Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry (PHAR).
Document Type
article
Author
Min, Jeff; Feng, Rui; Badesch, David; Berman-Rosenzweig, Erika; Burger, Charles; Chakinala, Murali; De Marco, Teresa; Feldman, Jeremy; Hemnes, Anna; Horn, Evelyn M; Lammi, Matthew R; Mathai, Stephen; McConnell, John W; Presberg, Kenneth; Robinson, Jeffrey; Sager, Jeffrey; Shlobin, Oksana; Simon, Marc; Thenappan, Thenappan; Ventetuolo, Corey; Al-Naamani, Nadine; Allen, Roblee; Bartolome, Sonja; Benza, Raymond; Bull, Todd; Cadaret, Linda; Eggert, Michael; Elwing, Jean; Fineman, Jeffrey; Foley, Raymond; Ford, H James; Frantz, Robert; Hirsch, Russel; Grinnan, James; Ivy, D Dunbar; Kawut, Steven; Kennedy, Jamie; Klinger, James; Leary, Peter; Mazimba, Sula; Ramani, Gautam; Raina, Amresh; Runo, James; Swisher, John; Ryan, John; Varghese, Nidhy; White, R James; Williamson, Timothy; Yung, Delphine; Zamanian, Roham; Zwicke, Dianne
Source
Annals of the American Thoracic Society. 18(2)
Subject
Language
Abstract
RationaleObesity is associated with pulmonary arterial hypertension (PAH), but its impact on outcomes such as health-related quality of life (HRQoL), hospitalizations and survival is not well understood.ObjectivesTo assess the effect of obesity on health-related quality of life (HRQoL), hospitalizations and survival in patients with PAH.MethodsWe performed a cohort study of adults with PAH from the Pulmonary Hypertension Association Registry, a prospective multicenter registry. Multivariate linear mixed effects regression was used to examine the relationship between weight categories and HRQoL using the Short Form-12 (SF-12) and emPHasis-10 (e10). We used multivariable negative binomial regression to estimate hospitalization incidence rate ratios (IRRs) and Cox regression to estimate hazard ratios (HRs) for transplant-free survival by weight status.Results767 subjects were included: mean age of 57 years, 74% female, 33% overweight and 40% obese, with median follow-up duration of 527 days. Overweight and obese patients had higher baseline e10 scores (worse HRQoL), which persisted over time (p