학술논문

The corrected donor age for hepatitis C virus–infected liver transplant recipients
Document Type
article
Source
Liver Transplantation. 21(8)
Subject
Biomedical and Clinical Sciences
Clinical Sciences
Organ Transplantation
Chronic Liver Disease and Cirrhosis
Hepatitis - C
Digestive Diseases
Emerging Infectious Diseases
Infectious Diseases
Liver Disease
Hepatitis
Transplantation
Good Health and Well Being
Adult
Age Factors
Decision Support Techniques
Donor Selection
End Stage Liver Disease
Female
Graft Survival
Hepatitis C
Humans
Likelihood Functions
Liver Transplantation
Male
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Proportional Hazards Models
Reproducibility of Results
Risk Assessment
Risk Factors
Time Factors
Tissue Donors
Treatment Outcome
United States
Surgery
Clinical sciences
Language
Abstract
Donor age has become the dominant donor factor used to predict graft failure (GF) after liver transplantation (LT) in hepatitis C virus (HCV) recipients. The purpose of this study was to develop and validate a model of corrected donor age (CDA) for HCV LT recipients that transforms the risk of other donor factors into the scale of donor age. We analyzed all first LT recipients with HCV in the United Network for Organ Sharing (UNOS) registry from January 1998 to December 2007 (development cohort, n = 14,538) and January 2008 to December 2011 (validation cohort, n = 7502) using Cox regression, excluding early GF ( 8 hours and -1 year/hour