학술논문
A 72-Week Randomized Study of the Safety and Efficacy of a Stavudine to Zidovudine Switch at 24 Weeks Compared to Zidovudine or Tenofovir Disoproxil Fumarate when Given with Lamivudine and Nevirapine
Document Type
article
Author
Phanuphak, Nittaya; Ananworanich, Jintanat; Teeratakulpisarn, Nipat; Jadwattanakul, Tanate; Kerr, Stephen J; Chomchey, Nitiya; Hongchookiat, Piranun; Mathajittiphun, Pornpen; Pinyakorn, Suteeraporn; Rungrojrat, Patcharawee; Praihirunyakit, Pairoa; Gerschenson, Mariana; Phanuphak, Praphan; Valcour, Victor; Kim, Jerome H; Shikuma, Cecilia
Source
Antiviral Therapy. 17(8)
Subject
Language
Abstract
BackgroundDue to superior long-term toxicity profiles, zidovudine (AZT) and tenofovir disoproxil fumarate (TDF) are preferred over stavudine (d4T) for first-line antiretroviral regimens. However, short-term d4T use could be beneficial in avoiding AZT-induced anaemia.MethodsWe randomized (1:1:1) 150 treatment-naive Thai HIV-infected adults with CD4(+) T-cell count