학술논문
Association of partial T2-FLAIR mismatch sign and isocitrate dehydrogenase mutation in WHO grade 4 gliomas: results from the ReSPOND consortium.
Document Type
article
Author
Lee, Matthew; Patel, Sohil; Mohan, Suyash; Akbari, Hamed; Bakas, Spyridon; Nasrallah, MacLean; Calabrese, Evan; Rudie, Jeffrey; LaMontagne, Pamela; Marcus, Daniel; Colen, Rivka; Balana, Carmen; Choi, Yoon; Badve, Chaitra; Barnholtz-Sloan, Jill; Sloan, Andrew; Booth, Thomas; Palmer, Joshua; Dicker, Adam; Flanders, Adam; Shi, Wenyin; Griffith, Brent; Poisson, Laila; Chakravarti, Arnab; Mahajan, Abhishek; Chang, Susan; Orringer, Daniel; Davatzikos, Christos; Jain, Rajan; Villanueva-Meyer, Javier
Source
Neuroradiology. 65(9)
Subject
Language
Abstract
PURPOSE: While the T2-FLAIR mismatch sign is highly specific for isocitrate dehydrogenase (IDH)-mutant, 1p/19q-noncodeleted astrocytomas among lower-grade gliomas, its utility in WHO grade 4 gliomas is not well-studied. We derived the partial T2-FLAIR mismatch sign as an imaging biomarker for IDH mutation in WHO grade 4 gliomas. METHODS: Preoperative MRI scans of adult WHO grade 4 glioma patients (n = 2165) from the multi-institutional ReSPOND (Radiomics Signatures for PrecisiON Diagnostics) consortium were analyzed. Diagnostic performance of the partial T2-FLAIR mismatch sign was evaluated. Subset analyses were performed to assess associations of imaging markers with overall survival (OS). RESULTS: One hundred twenty-one (5.6%) of 2165 grade 4 gliomas were IDH-mutant. Partial T2-FLAIR mismatch was present in 40 (1.8%) cases, 32 of which were IDH-mutant, yielding 26.4% sensitivity, 99.6% specificity, 80.0% positive predictive value, and 95.8% negative predictive value. Multivariate logistic regression demonstrated IDH mutation was significantly associated with partial T2-FLAIR mismatch (odds ratio [OR] 5.715, 95% CI [1.896, 17.221], p = 0.002), younger age (OR 0.911 [0.895, 0.927], p