학술논문
Inhibition of epidermal growth factor receptor restores decidualization markers in stromal fibroblasts from women with endometriosis
Document Type
article
Author
Source
Journal of Endometriosis and Pelvic Pain Disorders. 6(4)
Subject
Language
Abstract
Purpose: Decidualization comprises specific biochemical and morphological changes in uterine endometrium essential for establishment of pregnancy. This process is abnormal in women with endometriosis, a disorder in which endometrial-like tissue is present outside the uterus. The aim of this study was to restore cAMP-induced decidualization marker expression in endometrial stromal fibroblasts from women with endometriosis by using chemical inhibitors to PI3K/AKT/mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK) and epidermal growth factor receptor (EGFR) signaling pathways in vitro.