학술논문
Age-of-onset information helps identify 76 genetic variants associated with allergic disease.
Document Type
article
Author
Ferreira, Manuel AR; Vonk, Judith M; Baurecht, Hansjörg; Marenholz, Ingo; Tian, Chao; Hoffman, Joshua D; Helmer, Quinta; Tillander, Annika; Ullemar, Vilhelmina; Lu, Yi; Grosche, Sarah; Rüschendorf, Franz; Granell, Raquel; Brumpton, Ben M; Fritsche, Lars G; Bhatta, Laxmi; Gabrielsen, Maiken E; Nielsen, Jonas B; Zhou, Wei; Hveem, Kristian; Langhammer, Arnulf; Holmen, Oddgeir L; Løset, Mari; Abecasis, Gonçalo R; Willer, Cristen J; Emami, Nima C; Cavazos, Taylor B; Witte, John S; Szwajda, Agnieszka; 23andMe Research Team; collaborators of the SHARE study; Hinds, David A; Hübner, Norbert; Weidinger, Stephan; Magnusson, Patrik Ke; Jorgenson, Eric; Karlsson, Robert; Paternoster, Lavinia; Boomsma, Dorret I; Almqvist, Catarina; Lee, Young-Ae; Koppelman, Gerard H
Source
PLoS genetics. 16(6)
Subject
Language
Abstract
Risk factors that contribute to inter-individual differences in the age-of-onset of allergic diseases are poorly understood. The aim of this study was to identify genetic risk variants associated with the age at which symptoms of allergic disease first develop, considering information from asthma, hay fever and eczema. Self-reported age-of-onset information was available for 117,130 genotyped individuals of European ancestry from the UK Biobank study. For each individual, we identified the earliest age at which asthma, hay fever and/or eczema was first diagnosed and performed a genome-wide association study (GWAS) of this combined age-of-onset phenotype. We identified 50 variants with a significant independent association (P