학술논문

Intensive Blood Pressure Lowering in Individuals With Low Diastolic Blood Pressure and Elevated Troponin Levels in SPRINT
Document Type
article
Source
Journal of the American Heart Association. 13(6)
Subject
Biomedical and Clinical Sciences
Clinical Sciences
Clinical Trials and Supportive Activities
Hypertension
Cardiovascular
Heart Disease
Clinical Research
Aetiology
2.1 Biological and endogenous factors
Good Health and Well Being
Humans
Blood Pressure
Cardiovascular Diseases
Troponin
Risk Factors
Hypotension
Troponin T
Biomarkers
diastolic blood pressure
hypertension
J curve
SPRINT
troponin
Cardiorespiratory Medicine and Haematology
Cardiovascular medicine and haematology
Language
Abstract
BackgroundAmong individuals with hypertension and low diastolic blood pressure (DBP), the optimal BP target remains controversial due to concerns that BP lowering may reduce coronary perfusion. We determined the impact of intensive BP control among individuals with elevated systolic BP who have low DBP and elevated hs-cTnT (high-sensitivity cardiac troponin T) levels.Methods and resultsA total of 8828 participants in SPRINT (Systolic Blood Pressure Intervention Trial) were stratified by baseline DBP. Those with low DBP (