학술논문
Multi-ancestry fine mapping of interferon lambda and the outcome of acute hepatitis C virus infection
Document Type
article
Author
Vergara, Candelaria; Duggal, Priya; Thio, Chloe L; Valencia, Ana; O’Brien, Thomas R; Latanich, Rachel; Timp, Winston; Johnson, Eric O; Kral, Alex H; Mangia, Alessandra; Goedert, James J; Piazzola, Valeria; Mehta, Shruti H; Kirk, Gregory D; Peters, Marion G; Donfield, Sharyne M; Edlin, Brian R; Busch, Michael P; Alexander, Graeme; Murphy, Edward L; Kim, Arthur Y; Lauer, Georg M; Chung, Raymond T; Cramp, Matthew E; Cox, Andrea L; Khakoo, Salim I; Rosen, Hugo R; Alric, Laurent; Wheelan, Sarah J; Wojcik, Genevieve L; Thomas, David L; Taub, Margaret A
Source
Genes & Immunity. 21(5)
Subject
Language
Abstract
Clearance of acute infection with hepatitis C virus (HCV) is associated with the chr19q13.13 region containing the rs368234815 (TT/ΔG) polymorphism. We fine-mapped this region to detect possible causal variants that may contribute to HCV clearance. First, we performed sequencing of IFNL1-IFNL4 region in 64 individuals sampled according to rs368234815 genotype: TT/clearance (N = 16) and ΔG/persistent (N = 15) (genotype-outcome concordant) or TT/persistent (N = 19) and ΔG/clearance (N = 14) (discordant). 25 SNPs had a difference in counts of alternative allele >5 between clearance and persistence individuals. Then, we evaluated those markers in an association analysis of HCV clearance conditioning on rs368234815 in two groups of European (692 clearance/1 025 persistence) and African ancestry (320 clearance/1 515 persistence) individuals. 10/25 variants were associated (P