학술논문
Ghrelin Receptor Gene Polymorphisms and Body Size in Children and Adults
Document Type
Academic Journal
Author
Source
The Journal of Clinical Endocrinology & Metabolism. Oct 01, 2008 93(10):4158-4161
Subject
Language
English
ISSN
0021-972X
Abstract
BACKGROUND:: The GH secretagogue receptor type 1a gene (GHSR) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary GH secretion. Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth. AIM:: The aim of the study was to test common genetic variation in GHSR for association with body size in children and adults. METHODS:: Sequencing was performed to systematically identify novel single nucleotide polymorphisms (SNPs) in GHSR. A set of three haplotype-tagging SNPs that captured all the genetic variation in GHSR was identified. These three haplotype-tagging SNPs were then genotyped in three large population-based U.K. cohort studies (two adult and one childhood cohort) comprising 5807 adults and 843 children. RESULTS:: No significant genotype or haplotype associations were found with adult or childhood height, weight, or body mass index. CONCLUSION:: Common variation in GHSR is not associated with body size in U.K. adults or children.