학술논문
Immunophenotyping of interstitial infiltrate does not distinguish between BK virus nephropathy and acute cellular rejection
Document Type
Academic Journal
Source
Nephrology. Feb 01, 2009 14(1):118-122
Subject
Language
English
ISSN
1320-5358
Abstract
INTRODUCTION:: METHODS:: RESULTS:: Clustered B cells were demonstrated in both BKVN and ACR. Hence, the CD20-stained component within the interstitial infiltrate was not useful in distinguishing these biopsies. Perforin-stained slides demonstrated fewer cytotoxic T cells in the biopsies with BK virus (average 2.4 ± 1.4 cells per 100 lymphocytes per field) compared with those samples with acute rejection (8.6 ± 5.7 cells per 100 lymphocytes, P < 0.0001). No significant difference in granzyme B staining was detected between ACR and BKVN. CONCLUSION