학술논문
Noninvasive Ventilation and Weaning in Patients with Chronic Hypercapnic Respiratory Failure: A Randomized Multicenter Trial
Document Type
Academic Journal
Author
Source
American Journal of Respiratory and Critical Care Medicine. Sep 15, 2011 184(6):672-679
Subject
Language
English
ISSN
1073-449X
Abstract
RATIONALE:: OBJECTIVES:: METHODS:: MEASUREMENTS AND MAIN RESULTS:: Reintubation rates were 30, 37, and 32% for invasive weaning, oxygen-therapy, and NIV groups, respectively (P = 0.654). Weaning failure rates, including postextubation ARF, were 54, 71, and 33%, respectively (P < 0.001). Rescue NIV success rates for invasive and oxygen-therapy groups were 45 and 58%, respectively (P = 0.386). By design, intubation duration was 1.5 days longer for the invasive group than in the two others. Apart from a longer weaning time in NIV than in invasive group (2.5 vs. 1.5 d; P = 0.033), no significant outcome difference was observed between groups. CONCLUSIONS:: Clinical trial registered with www.clinicaltrials.gov (NCT 00213499).