학술논문
Risk of childhood leukaemia and non-Hodgkinʼs lymphoma after parental occupational exposure to solvents and other agents: the SETIL Study
Document Type
Academic Journal
Author
Miligi, Lucia; Benvenuti, Alessandra; Mattioli, Stefano; Salvan, Alberto; Tozzi, Giulio Andrea; Ranucci, Alessandra; Legittimo, Patrizia; Rondelli, Roberto; Bisanti, Luigi; Zambon, Paola; Cannizzaro, Santina; Kirchmayer, Ursula; Cocco, Pierluigi; Celentano, Egidio; Assennato, Giorgio; Merlo, Domenico Franco; Mosciatti, Paola; Minelli, Liliana; Cuttini, Marina; Torregrossa, Valeria; Lagorio, Susanna; Haupt, Riccardo; Risica, Serena; Polichetti, Alessandro; Monetti, Daniele; Veneto, Istituto Oncologico; Gafà, Lorenzo; Luzzatto, Lia Lidia; Michelozzi, Paola; Forastiere, Francesco; Gelli, Luigi; Assennato, Giorgio; Pannelli, Franco; Chiavarini, Manuela; Lippi, Alma; Bernini, Gabriella; Nardi, Margherita; Acquaviva, Antonio; Adesi, Francesco Barone; Cavariani, Fulvio; Belletti, Isabella; Troeschel, Loredana; Calisti, Roberto; Silvestri, Stefano; Sommani, Letizia; Miceli, Giuseppe; Farioli, Andrea; Magnani, Corrado
Source
Occupational and Environmental Medicine. Sep 01, 2013 70(9):648-655
Subject
Language
English
ISSN
1351-0711
Abstract
AIM: In the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkinʼs Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures. METHODS: All cases of childhood leukaemia and non-Hodgkinʼs lymphoma (NHL) in children aged 0–10 years were identified. Controls were chosen at random from the local population in each region. Parents were interviewed using a structured questionnaire. The collected data were blindly reviewed by expert industrial hygienists in order to estimate exposure to a list of agents. Statistical analyses were performed for each agent using unconditional multivariable logistic regression models, taking into account timing of exposure. RESULTS: 683 cases of acute childhood leukaemia, 97 cases of NHL and 1044 controls were identified. Increased risk of childhood leukaemia was found for maternal exposure to aliphatic (OR 4.3) or aromatic hydrocarbons (OR 3.8) in the preconception period, and for paternal exposure to diesel exhaust (OR 1.4), lead exposure (OR 1.4) and mineral oils (OR 1.7). Risk of NHL appeared to be related to paternal exposure to oxygenated solvents (OR 2.5) and petrol exhaust (OR 2.2). CONCLUSIONS: We found increased risk for childhood leukaemia associated with maternal occupational exposure to aromatic and aliphatic hydrocarbons, particularly in the preconception period; increased risks were also observed for paternal exposure to diesel exhaust fumes, mineral oils and lead. The risk of NHL appeared to be related to paternal exposure to oxygenated solvent and petrol exhausts.