학술논문
Impact of Surgery on Oligometastatic Pancreatic Cancer: Current Status and Future Perspectives
Document Type
Article
Source
(2023): 1-8.
Subject
Language
Korean
ISSN
29509394
Abstract
Pancreatic cancer treatment has advanced. In particular, effective chemotherapy regimendevelopment has fundamentally altered the therapeutic concept and strategy for pancreaticcancer treatment. Consequently, the prognosis of patients with pancreatic cancer has graduallyimproved. Conversion surgery for locally advanced pancreatic cancer may offer long-term survival or even a full recovery in some individuals. In contrast, metastatic pancreatic cancer haslong been considered a surgical contraindication because aggressive surgical resection of themetastatic lesions does not prolong patient survival. Unexpectedly positive benefits of anticancer therapy in recent clinical experience were observed even with metastatic pancreatic cancer. To date, little evidence presented the success of surgical resection for metastatic pancreatic cancer treatment in such rare cases. However, hope and concern are growing that surgical intervention, even in patients with metastatic cancer, may result in favorable outcomes. Several studiessuggested different surgical intervention effects depending on metastasis sites and patterns. Thus, this review summarizes the current status of surgery in the multidisciplinary treatment ofoligometastatic pancreatic cancer and discusses future perspectives.
Pancreatic cancer treatment has advanced. In particular, effective chemotherapy regimendevelopment has fundamentally altered the therapeutic concept and strategy for pancreaticcancer treatment. Consequently, the prognosis of patients with pancreatic cancer has graduallyimproved. Conversion surgery for locally advanced pancreatic cancer may offer long-term survival or even a full recovery in some individuals. In contrast, metastatic pancreatic cancer haslong been considered a surgical contraindication because aggressive surgical resection of themetastatic lesions does not prolong patient survival. Unexpectedly positive benefits of anticancer therapy in recent clinical experience were observed even with metastatic pancreatic cancer. To date, little evidence presented the success of surgical resection for metastatic pancreatic cancer treatment in such rare cases. However, hope and concern are growing that surgical intervention, even in patients with metastatic cancer, may result in favorable outcomes. Several studiessuggested different surgical intervention effects depending on metastasis sites and patterns. Thus, this review summarizes the current status of surgery in the multidisciplinary treatment ofoligometastatic pancreatic cancer and discusses future perspectives.
Pancreatic cancer treatment has advanced. In particular, effective chemotherapy regimendevelopment has fundamentally altered the therapeutic concept and strategy for pancreaticcancer treatment. Consequently, the prognosis of patients with pancreatic cancer has graduallyimproved. Conversion surgery for locally advanced pancreatic cancer may offer long-term survival or even a full recovery in some individuals. In contrast, metastatic pancreatic cancer haslong been considered a surgical contraindication because aggressive surgical resection of themetastatic lesions does not prolong patient survival. Unexpectedly positive benefits of anticancer therapy in recent clinical experience were observed even with metastatic pancreatic cancer. To date, little evidence presented the success of surgical resection for metastatic pancreatic cancer treatment in such rare cases. However, hope and concern are growing that surgical intervention, even in patients with metastatic cancer, may result in favorable outcomes. Several studiessuggested different surgical intervention effects depending on metastasis sites and patterns. Thus, this review summarizes the current status of surgery in the multidisciplinary treatment ofoligometastatic pancreatic cancer and discusses future perspectives.