학술논문

Diagnostic Challenges during Pretreatment Long-term Follow-up in a Patient with FIP1L1-PDGFRA-positive Eosinophilia
Document Type
Journal Article
Source
Internal Medicine. 2015, 54(6):637
Subject
PDGFRA
eosinophilia
imatinib
Language
English
ISSN
0918-2918
1349-7235
Abstract
Obtaining a precise characterization of eosinophilia is crucial, as successful treatment relies on the underlying etiology of the disease. Platelet-derived growth factor receptor alpha-related disorders were first specified in 2008 as a distinct group of clonal eosinophilic disorders with exceptional responsiveness to imatinib. We herein present the case of a man with myeloid neoplasm and eosinophilia in whom a definitive diagnosis could not be adequately made based on histopathological features who was ultimately diagnosed only after extensive molecular analyses and successfully treated with imatinib. In addition, we discuss the diagnostic and therapeutic approaches to treating patients presenting with eosinophilia.