학술논문
Analysis of cardiohemodynamic and electrophysiological effects of morphine using the halothane-anesthetized dogs / ハロセン麻酔犬を用いたmorphineによる心血行動態および電気生理学的作用の分析
Document Type
Journal Article
Author
Source
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2023, :3-2
Subject
Language
Japanese
ISSN
2435-4953
Abstract
Results: The low dose hardly altered cardiovascular variables. The high dose reduced preload and afterload to the left ventricle for 5-15 min after the start of infusion, then decreased the left ventricular contractility along with the mean blood pressure for 10-30 min, and next suppressed the heart rate for 15-30 min. Morphine slowed the atrioventricular conduction and ventricular late repolarization, and prolonged the ventricular effective refractory period without altering the intraventricular conduction or ventricular early repolarization. A reverse-frequency-dependent delay of ventricular repolarization was confirmed.