학술논문
Thromboxane A2 receptor signaling in macrophages promotes liver repair after acetaminophen-induced liver injury / マクロファージにおけるトロンボキサンA2受容体シグナルはアセトアミノフェン誘導肝障害後の肝修復を促進する
Document Type
Journal Article
Author
Source
Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2023, :2-2
Subject
Language
Japanese
ISSN
2435-4953
Abstract
Objective: Acetaminophen (APAP) overdose causes severe acute liver failure. Impaired liver repair and regeneration after APAP hepatotoxicity leads to failed recovery and mortality. Accumulating evidence indicates that macrophages play a critical role in liver repair after APAP-induced liver injury; however, underlying mechanisms of involvement of macrophages remain unknown. Here, we examined the role of endogenous thromboxane A2 (TXA2) in macrophages in liver repair after APAP-induced liver injury.