학술논문
HIV-Specific Cellular Immune Response Is Inversely Correlated with Disease Progression as Defined by Decline of CD4⁺ T Cells in Relation to HIV RNA Load
Document Type
research-article
Author
Source
The Journal of Infectious Diseases, 2004 Apr 01. 189(7), 1199-1208.
Subject
Language
English
ISSN
00221899
Abstract
The average time between infection with human immunodeficiency virus (HIV) and development of acquired immune deficiency syndrome is ~8 years. However, progression rates vary widely, depending on several determinants, including HIV-specific immunity, host genetic factors, and virulence of the infecting strain. In untreated HIV-infected patients with different progression rates, we examined HIV-specific T cell responses in combination with host genetic markers, such as chemokine/chemokine-receptor (CCR) polymorphisms and human leukocyte antigen (HLA) genotypes. HIV-specific CD4⁺ T cell responses and, to a lesser extent, HIVspecific CD8⁺ T cell responses were inversely correlated with progression rate. Slower progression was not related to polymorphisms in CCR genes, HLA genotype, or GB virus C coinfection. These data suggest that HIV-specific T cell responses are involved in protecting the host from disease progression.