학술논문
The p53 Tumor Suppressor Targets a Novel Regulator of G Protein Signaling
Document Type
research-article
Author
Source
Proceedings of the National Academy of Sciences of the United States of America, 1997 Jul . 94(15), 7868-7872.
Subject
Language
English
ISSN
00278424
Abstract
Heterotrimeric G proteins transduce multiple growth-factor-receptor-initiated and intracellular signals that may lead to activation of the mitogen-activated or stress-activated protein kinases. Herein we report on the identification of a novel p53 target gene (A28-RGS14) that is induced in response to genotoxic stress and encodes a novel member of a family of regulators of G protein signaling (RGS) proteins with proposed GTPase-activating protein activity. Overexpression of A28-RGS14p protein inhibits both G i - and G q - coupled growth-factor-receptor-mediated activation of the mitogen-activated protein kinase signaling pathway in mammalian cells. Thus, through the induction of A28-RGS14, p53 may regulate cellular sensitivity to growth and/or survival factors acting through G protein-coupled receptor pathways.