학술논문
Test-retest variability of quantitative [[.sup.11]C]PIB studies in Alzheimer's disease
Document Type
Report
Author
Source
European Journal of Nuclear Medicine and Molecular Imaging. Oct, 2009, Vol. 36 Issue 10, p1629, 10 p.
Subject
Language
English
ISSN
1619-7070
Abstract
Purpose The aim of this study was to assess the test-retest variability of [[.sup.11]C]PIB studies in patients with Alzheimer's disease (AD) and healthy controls using several tracer kinetic models and to assess the suitability of the cerebellum as reference tissue. Methods [11C]PIB studies with arterial sampling were performed in eight AD patients and eight healthy controls. Retest scans were performed in six controls and six AD patients. Data were analysed using plasma input and reference tissue models, together with simple ratios. Results Test-retest variability was best ([proportional to]3%) for SRTM2, a parametric method based on the simplified reference tissue model. Highest values ([proportional to]10%) were found for plasma input models. Cerebellar V.sub.T values did not differ significantly between AD and controls. Conclusion Parametric SRTM2 with the cerebellum as reference tissue is the method of choice for quantitative analysis of [[.sup.11]C]PIB PET studies.