학술논문

Examination of Common Coronavirus Antibodies in SARS-CoV-2-Infected and Uninfected Participants in a Household Transmission Investigation
Document Type
Academic Journal
Source
Open Forum Infectious Diseases. July, 2022, Vol. 9 Issue 7
Subject
Company legal issue
Viral antibodies -- Investigations
B cells -- Investigations
Proteins -- Investigations
Severe acute respiratory syndrome -- Investigations
Antibodies -- Investigations
Coronaviruses -- Investigations
United States. Centers for Disease Control and Prevention -- Investigations
Language
English
Abstract
We compared paired serum specimens from household contacts of severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) cases with detectable SARS-CoV-2 seroconversion with contacts who remained seronegative. No protection from SARS-CoV-2 infection was associated with human coronavirus antibodies; however, an increase in common betacoronavirus antibodies was associated with seroconversion to SARS-CoV-2 in mild to moderately ill cases. Keywords. common coronaviruses; COVID-19; human coronaviruses; immunology; SARS-CoV-2.
While the understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to evolve, knowledge of the immune response to SARS-CoV-2 is currently limited. Four other more common human [...]