학술논문
Predictors of postoperative hypocalcemia occurring after a total thyroidectomy: results of prospective multicenter study
Document Type
Report
Author
Source
BMC Surgery. August 9, 2018, Vol. 18 Issue 1
Subject
Language
English
ISSN
1471-2482
Abstract
Author(s): Vitalijus Eismontas[sup.1] , Algirdas Slepavicius[sup.1] , Vinsas Janusonis[sup.1] , Paulius Zeromskas[sup.1] , Virgilijus Beisa[sup.2] , Kestutis Strupas[sup.2] , Zilvinas Dambrauskas[sup.3] , Antanas Gulbinas[sup.3] and Arvydas Martinkenas[sup.4] Background Thyroid surgeries [...]
Background Thyroid surgeries are among the most common operations performed in the world. Hypocalcemia following total thyroidectomy is a common complication that is sometimes difficult to correct. The aim of this study is to determine the risk factors for hypocalcemia following total thyroidectomy and their clinical value. Methods From January 2015 through to April 2017, 400 patients were included in this prospective multicenter study. All patients underwent total thyroidectomy due to various thyroid diseases. The following risk factors were analyzed: pre-operative and post-operative biochemical blood parameters, clinical effects and factors related to surgery, the patient, and the disease. Results Post-operative hypocalcemia developed in 257 patients (64.2%). Of them, 197 patients (76.7%) were diagnosed with asymptomatic hypocalcemia. Clinical symptoms were present in 60 of the 257 patients with hypocalcemia (23.3%). The statistically significant predictors of hypocalcemia were decreased calcium and ionized calcium pre-operatively (p < 0.001), parathyroid hormone on day one following surgery (p < 0.001), thyrotoxicosis Conclusions This study demonstrates that there is a number of different patient (gender, age, and duration of thyrotoxicosis Keywords: Total thyroidectomy, Hypocalcemia, Thyroid surgery, Predictors
Background Thyroid surgeries are among the most common operations performed in the world. Hypocalcemia following total thyroidectomy is a common complication that is sometimes difficult to correct. The aim of this study is to determine the risk factors for hypocalcemia following total thyroidectomy and their clinical value. Methods From January 2015 through to April 2017, 400 patients were included in this prospective multicenter study. All patients underwent total thyroidectomy due to various thyroid diseases. The following risk factors were analyzed: pre-operative and post-operative biochemical blood parameters, clinical effects and factors related to surgery, the patient, and the disease. Results Post-operative hypocalcemia developed in 257 patients (64.2%). Of them, 197 patients (76.7%) were diagnosed with asymptomatic hypocalcemia. Clinical symptoms were present in 60 of the 257 patients with hypocalcemia (23.3%). The statistically significant predictors of hypocalcemia were decreased calcium and ionized calcium pre-operatively (p < 0.001), parathyroid hormone on day one following surgery (p < 0.001), thyrotoxicosis Conclusions This study demonstrates that there is a number of different patient (gender, age, and duration of thyrotoxicosis Keywords: Total thyroidectomy, Hypocalcemia, Thyroid surgery, Predictors