부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bbr.2005.05.011 Byline: Mark Day, Amy Sung, Sheree Logue, Mark Bowlby, Robert Arias Abstract: Estrogen has marked effects on hippocampal synaptic plasticity. We demonstrate that male and female 3-month-old beta estrogen receptor knockout (BERKO) mice show profound memory impairment in a hippocampus-mediated fear-conditioning paradigm. Subsequently, hippocampal slices prepared from behaviorally naive female BERKO mice were examined electrophysiologically. These were found to have robust synaptic deficits, compared to slices from age-matched wild type controls, both in terms of their input-output curves and their expression of long-term-potentiation in area CA1. This report provides the first concrete evidence of significant hippocampal synaptic plasticity and memory deficits in the BERKO mouse. Author Affiliation: Wyeth Research, Discovery Neuroscience, CN8000, Princeton, NJ 08543, USA Article History: Received 14 March 2005; Revised 4 May 2005; Accepted 9 May 2005