학술논문
A gain-of-function mutation of JAK2 in myeloproliferative disorders
Document Type
Academic Journal
Author
Source
The New England Journal of Medicine. April 28, 2005, Vol. 352 Issue 17, p1779, 12 p.
Subject
Language
English
ISSN
0028-4793
Abstract
The loss of heterozygosity (LOH) on the short arm of chromosome 9 (9pLOH) in myeloproliferative disorders suggests that 9p harbors a mutation that contributes to the cause of clonal expansion of hematopoietic cells in these diseases. A high proportion of patients with myeloproliferative disorders carry a dominant gain-of-function mutation of JAK2.