학술논문
Analysis of HER-2/neu Receptor Expression and the Level of Neuronal Apoptosis in HER-2/neu Transgenic Mice during Aging
Document Type
Academic Journal
Source
Bulletin of Experimental Biology and Medicine. August, 2019, Vol. 167 Issue 4, p512, 4 p.
Subject
Language
English
ISSN
0007-4888
Abstract
We studied neuronal death in the sensorimotor cortex, hippocampus, and supraoptic and paraventricular nuclei of the hypothalamus and dynamics of HER-2/neu expression in late ontogenesis in young and old transgenic HER-2/neu mice. Wild-type FVB/N mice served as the control. The intensity of apoptosis (TUNEL) and HER-2/neu expression (Western blotting) in the same brain regions were measured. HER-2/neu was detected in the cortex, hippocampus, and hypothalamus of transgenic and wild-type mice, and its expression increased with age. The effect of HER-2/neu on the intensity of cell death in various brain regions depended on the stage of ontogenesis and animal genotype. Enhanced expression of HER-2/neu determines low rate of cell death in the studied brain regions during pathological ageing. Key Words: HER-2/neu; aging; sensorimotor cortex; hippocampus; hypothalamus
HER (human epidermal growth factor receptor) receptors family consists of 4 membrane proteins containing ligand-binding, transmembrane, and intracellular domains [8]. HER proteins contribute to the regulation of apoptosis, proliferation, and [...]
HER (human epidermal growth factor receptor) receptors family consists of 4 membrane proteins containing ligand-binding, transmembrane, and intracellular domains [8]. HER proteins contribute to the regulation of apoptosis, proliferation, and [...]